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DNAgard Blood
Collect, Preserve and Transport Whole Blood at Room Temperature.
DNAgard® Blood is designed for the immediate stabilization of DNA in blood with the convenience of room temperature shipping and storage. The preservative reagent rapidly permeates cellular structures and membranes to stabilize and protect genomic DNA in whole blood samples. The use of DNAgard Blood allows a streamlined workflow from blood collection in the clinic or field to sample processing in the laboratory.
Technology Overview:
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Features & BenefitsSample Integrity
Compatible with different extraction/purification techniques Easy handling and shipping Environmentally friendly: No dry ice required Compatible with all downstream applications |
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Stabilization of DNA at Room Temperature - Convenient Shipping.
DNAgard Blood rapidly mixes with blood and penetrates cells to stabilize and protect genomic DNA for at least 8 months at room temperature (Figure 1). DNAgard Blood also protects DNA in whole blood subjected to temperature fluctuations during sample shipping from collection site to processing lab (Figure 2).
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Figure 1. DNAgard Blood protects DNA for up to 8 months. Gel images of isolated genomic DNA from whole blood samples obtained from 4 donors after 8 months of storage at room temperature in DNAgard Blood (DGB), non-protected (NP), competitor (Comp), and at -20C.
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Figure 2. DNAgard Blood protects DNA in various temperature conditions Gel image of extracted DNA from bood samples were stored in DNAgard Blood (DGB), non-protected (NP) or in competitor’s stabilizer and exposed to a 13 days-simulated shipping cycle with temperature fluctuations between -20°C and 45°C. Following samples were stored for 36 days at ambient room temperature before DNA extraction. (M = 1kb ladder)..
Broad range of applications
DNA protected using DNAgard is suitable for use in many downstream applications, e.g. long-range PCR, real time PCR, etc.
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Figure 3A . Successful Long-range PCR after 2 months storage. Genomic DNA isolated from human whole blood stored for 60 days in DNAgard Blood (DGB), non-protected (NP) or frozen at -20°C. Long-range PCR amplification of a 22 Kbp amplicon was performed on the DNA (M = 1 kb ladder).
Figure 3B. Real-time PCR after 1 month storage. Genomic DNA isolated from human whole blood stored for 30 days in DNAgard Blood (DGB) or frozen at -20°C was quantified using real-time PCR amplification of the b-actin gene.
Representative DNA yield
DNA protected using DNAgard is suitable for use in many downstream applications, e.g. long-range PCR, real time PCR, etc.
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Figure 4. qPCR quantification after 1 month storage of blood, from 3 different donors, in DNAgard Blood (RT), Competitor (RT) or frozen (-20°C).
