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DNAstable Validation Kit
The Biomatrica Forensic Validation Kit is designed to enable the DNA section of a forensic laboratory to quickly and easily validate the long-term storage of DNA extracts at room temperature in Biomatrica’s DNAstable. The kit and protocols meet the standard validation requirements established by the Scientific Working Group on DNA Analysis Methods SWGDAM) and by the Federal Bureau of Investigation Quality Assurance Standards (FBI/QAS) for achieving quality assurance standards for forensic DNA testing laboratories.
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Examples of evaluation studies by Forensic scientists
Long-term storage of gDNA in DNAstable.
Palm Beach County Sheriff's Office - Dr. Cecilia A. Crouse, Chief Scientific Officer
The study involved a rigorous evaluation of stabilization of forensic DNA samples using Biomatrica's DNAstable (room temperature) and cold freezers (-20C), at various sample concentrations (0.5ng to 4 ng), for 12 months. A highlight of the results obtained in the study is shown below:
The study was published in the Forensic Science International - Genetics, 2011 (see reference section below for link).
Los Angeles County Sheriff's Department - Gregory M. Hadinoto, Senior Criminalist
DNA extracts from 3 different sample types - blood, semen and buccal cells were stored dry in DNAstable at room temperature as well as frozen at -20C (control) for 45 months. After rehydration (DNAstable-matrix) and freeze/thaw (cold-frozen), the recovery and STR profiles of the samples were determined. STR profile results show no allelic drop-outs in all samples stored frozen or at ambient temperatures over 45 months. Higher DNA recovery were observed for DNAstable-stored samples over frozen samples as displayed below.
Biomatrica has developed a range of products for forensic scientists in biological evidence collection, transportation, storage, and processing. DNA extracts from different sample types (blood, semen, buccal, etc) can be preserved for long-time at room temperature with high quality and high yield. Our room temperature DNA stabilization reagents as well as assay enhancement products (see below) have been well validated by several forensic scientists and laboratories. A detailed listing of these validations and publications is also provided below.
List of publications, scientific posters, and application notes
Davis, M.C., Le, L., Clabaugh, K., Trogdon, C., Nhan, P., Odigie, K., Lee, S., Hampikian, G. The PCR enhancer PCRboost™ overcomes inhibitors in STR and mitochondrial microsequencing reactions. 2011. Forensic Science International - Genetics. Submitted.
Linda Le, Kimberly Clabaugh, Clarisa Trogdon, Andrew Chang, Marissa Meininger, Michael D. Coble, Odile Loreille, Melissa Scheibel, Rachel Demara, Sohela de Rozieres, Martin Latterich, Rolf Muller and Steven B. Lee. Recovering DNA profiles from low quantity and low quality forensic samples Recovering DNA profiles from low quantity and low quality forensic samples. A poster presentation at the 19th International Symposium on Human Identification meeting, Holywood, CA, October 2008.
Kimberly Clabaugh, Brie Silva, Kingsley Odigie, Ron Fourney, Jesse Stevens, George Carmody, Mike Coble, Odile Loreille, Melissa Scheible, Margaret Kline, Thomas Parsons, Arijana Pozder, Arthur Eisenberg, Bruce Budowle and Steven B. Lee. 2007 and 2008Storage of DNA samples at ambient temperature using DNA-SampleMatrix. Poster presented at the 18th Annual International Symposium on Human Identification. October, 2007, Hollywood, CA. Also presented as an oral presentation at the Fall 2007 California Association of Criminalists Meeting held in Berkeley, CA October 2007, the American Academy of Forensic Sciences February 2008 meeting held in Washington DC. Published in the Proceedings of the American Academy of Forensic Sciences. Volume 14. page 51 - and the Spring 2008 California Association of Criminalists meeting, May 2008, San Diego, CA.